ABCD2 / ALDR

ATP-binding cassette, sub-family D (ALD), member 2

ABCD2 / ALDR is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

ABCD2 / ALDR (3)

Publications

No (3)

Tag

His-T7, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (1)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

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Mouse ABCD2 / ALDR Protein (Recombinant His-T7, N-terminus) (Lys501-Leu695) - LS-G133439

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

26.0kDa

Price:

10 µg/$273; 50 µg/$392; 200 µg/$785; 100 µg/$627; 1 mg/$1,852; 500 µg/$1,409; 5 mg/$2,814; 2 mg/$2,035

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Human ABCD2 / ALDR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84894

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.1 kDa

Price:

20 µg/$150

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ABCD2 / ALDR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116137

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.1 kDa

Price:

100 µg/$494

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