ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

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Products

ELISA Kits (7)

Type

Cell-Based Phosphorylation (1)

Sandwich (4)

Sandwich CLIA (2)

Target

ABL2 (7)

Reactivity

Human (1)

Mouse (2)

Rat (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (1)

96-Well Strip Plate (4)

Publications

No (7)

Sample Type

Adherent Cell Cultures (1)

Plasma (2)

Serum (2)

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Rat ABL2 (CLIA) ELISA Kit - LS-F31095

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse ABL2 (CLIA) ELISA Kit - LS-F30507

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Porcine ABL2 (Sandwich ELISA) ELISA Kit - LS-F41443

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

7.813 - 500 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig ABL2 (Sandwich ELISA) ELISA Kit - LS-F41442

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey ABL2 (Sandwich ELISA) ELISA Kit - LS-F41445

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

7.813 - 500 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit ABL2 (Sandwich ELISA) ELISA Kit - LS-F41444

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

7.813 - 500 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Mouse/Human Phospho-ABL2 (Tyr393/412) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1760

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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