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Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
Gene Name: | acetyl-CoA carboxylase alpha |
Synonyms: | ACACA, ACAC, ACC1, ACACAD, ACCA, ACC, ACC-alpha, Acetyl-CoA Carboxylase, Acetyl-CoA carboxylase 1, Acetyl-CoA carboxylase alpha |
Target Sequences: | Q13085 Q13085 |
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