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ACHE / Acetylcholinesterase

acetylcholinesterase

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.

Gene Name: acetylcholinesterase
Synonyms: ACHE, ACEE, Acetylcholinesterase, N-ACHE, Yt blood group, ARACHE, YT
Target Sequences: NM_015831 P22303 P22303

Publications (1)

1
Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands. Yiyu Wang, Jörg Scheffel, Carolina Ayala Vera, Wei Liu, Dorothee Günzel, Dorothea Terhorst-Molawi, Marcus Maurer, Sabine Altrichter. Frontiers in immunology. 2022 August;13:955161. [Full Text Article] [PubMed:35967390] [PMC:PMC9373796] Related Antibodies: LS-B6676.

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ACHE / Acetylcholinesterase (28)
Human (6)
Mouse (6)
Rat (8)
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Guinea pig (1)
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96-Well Microplate (1)
96-Well Strip Plate (26)
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Cell Supernatant (1)
Plasma (21)
Serum (21)
Tissue Homogenates (11)
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
0.16 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
ACHE / Acetylcholinesterase ELISA Kit
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Competitive EIA
96-Well Strip Plate
Fish
2.5 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$818
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ACHE / Acetylcholinesterase ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
ACHE / Acetylcholinesterase ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
ACHE / Acetylcholinesterase ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$820
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ACHE / Acetylcholinesterase ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
ACHE / Acetylcholinesterase ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
ACHE / Acetylcholinesterase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 IU/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).