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ACIN1 / Acinus

apoptotic chromatin condensation inducer 1

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.

Gene Name: apoptotic chromatin condensation inducer 1
Family/Subfamily: Apoptosis
Synonyms: ACIN1, ACINUS, ACN, KIAA0670, FSAP152
Target Sequences: NM_014977 NP_055792.1 Q9UKV3

Publications (1)

1
Function of cell-cycle regulators in predicting silent pituitary adenoma progression following surgical resection. Park SH, Jang JH, Lee YM, Kim JS, Kim KH, Kim YZ. Oncology letters. 2017 December;14:7121-7130. (Human) [Full Text Article] [PubMed:29344143] [PMC:PMC5754893]

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ACIN1 / Acinus (5)
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GST, N-terminus (1)
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293T Cells (2)
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Wheat Germ Extract (1)
ACIN1 / Acinus Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
70.8 kDa
20 µg/$150
ACIN1 / Acinus Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
67.4 kDa
20 µg/$150
ACIN1 / Acinus Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
ACIN1 / Acinus Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
67.4 kDa
100 µg/$494
ACIN1 / Acinus Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
70.8 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).