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ACKR2 / CCR10 / D6

atypical chemokine receptor 2

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.

Gene Name: atypical chemokine receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: ACKR2, C-C chemokine receptor D6, CCBP2, Chemokine (C-C) receptor 9, Chemokine binding protein 2, C-C chemokine receptor 10, Chemokine-binding protein 2, CMKBR9, Chemokine receptor CCR-9, G protein coupled receptor d6, HD6, Cc-chemokine receptor type 10, Chemokine receptor CCR-10, Chemokine receptor D6, Chemokine-binding protein D6, D6
Target Sequences: NM_001296 NP_001287.2 O00590

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
ACKR2 / CCR10 / D6 (5)
No (5)
GST (2)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
ACKR2 / CCR10 / D6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
43.3 kDa
100 µg/$494
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293T Cells
Myc-DDK (Flag)
43.3 kDa
20 µg/$150
ACKR2 / CCR10 / D6 Protein - 12.5% SDS-PAGE of human CCBP2 stained with Coomassie Blue
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Wheat Germ Extract
GST
67.98 kDa
2 µg/$439
ACKR2 / CCR10 / D6 Protein - 12.5% SDS-PAGE of human CCBP2 stained with Coomassie Blue
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Wheat Germ Extract
GST
69.8 kDa
2 µg/$439
ACKR2 / CCR10 / D6 Protein - Purified recombinant protein ACKR2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
43.3 kDa
20 µg/$1,107
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).