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ACKR3 / CXCR7

atypical chemokine receptor 3

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

Gene Name: atypical chemokine receptor 3
Family/Subfamily: GPCR , Chemokine
Synonyms: ACKR3, Chemokine orphan receptor 1, CMKOR1, CXCR7, CXC-R7, GPRN1, RDC1, RDC-1, CXCR-7, G-protein coupled receptor 159, GPR159
Target Sequences: NM_020311 NP_064707.1 P25106

Publications (6)

1
Fluctuations in Blood Marginal Zone B-Cell Frequencies May Reflect Migratory Patterns Associated with HIV-1 Disease Progression Status. Gauvin J, Chagnon-Choquet J, Poudrier J, Roger M,; Montreal Primary HIV Infection and Slow Progressor Cohorts. PloS one. 2016 11:e0155868. (Flo; Human) [Full Text Article] [PubMed:27203285] [PMC:PMC4874627] Related Antibodies: LS-C64035.
2
New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle. Evans AE, Tripathi A, LaPorte HM, Brueggemann LI, Singh AK, Albee LJ, Byron KL, Tarasova NI, Volkman BF, Cho TY, Gaponenko V, Majetschak M. International journal of molecular sciences. 2016 17: (Flo, PLA; Mouse, Human) [Full Text Article] [PubMed:27331810] [PMC:PMC4926503] Related Antibodies: LS-B1815.
3
Commercially available antibodies directed against a-adrenergic receptor subtypes and other G protein-coupled receptors with acceptable selectivity in flow cytometry experiments. Abhishek Tripathi, Vadim Gaponenko, Matthias Majetschak. Naunyn-Schmiedeberg's archives of pharmacology. 2016 Feb;389:243-8. [Full Text Article] [PubMed:26660071] [PMC:PMC4718873] Related Antibodies: LS-B1815.
4
The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover. Jones SW, Brockbank SM, Mobbs ML, Le Good NJ, Soma-Haddrick S, Heuze AJ, Langham CJ, Timms D, Newham P, Needham MR. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2006 Jun;14:597-608. [Full Text Article] [PubMed:16647866] Related Antibodies: LS-A1893.
5
Heteromerization of chemokine (C-X-C motif) receptor 4 with alpha 1A/B-adrenergic receptors controls alpha 1-adrenergic receptor function. Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M. Proceedings of the National Academy of Sciences of the United States of America. Mar; (PLA; Human, Rat) [Full Text Article] [PubMed:25775528] Related Antibodies: LS-B1815.
6
The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. Singh RK, Lokeshwar BL. Cancer research. 2011 May;71:3268-77. [Full Text Article] [PubMed:21398406] [PMC:PMC3085571] Related Antibodies: LS-A1439.
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Antibodies (43)
Primary (43)
ACKR3 / CXCR7 (43)
Human (43)
Mouse (19)
Rat (12)
Bat (2)
Bovine (2)
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Hamster (2)
Horse (3)
Monkey (2)
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IHC (11)
IHC-P (6)
WB (35)
Flo (16)
ELISA (18)
IF (5)
IP (2)
Peptide-ELISA (4)
rabbit (35)
mouse (7)
goat (1)
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GPCR Database Antibodies (2)
IHCPlus (3)
PathPlus Neuro (1)
IgG (25)
IgG1 (3)
IgG2a (3)
IgG2b,k (1)
monoclonal mc (7)
polyclonal pc (36)
11n55 (1)
8F11-M16 (1)
APC Conjugated (3)
Azide-free (2)
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CF Conjugated (1)
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Unconjugated (26)
aa330-358 (7)
aa333-362 (7)
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290-370 aa, C-terminal (1)
Ala356 (1)
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aa100-150 (1)
aa307-356 (1)
aa311-360 (1)
No (39)
Yes (4)
ACKR3 / CXCR7 Antibody - Anti-ACKR3 / CXCR7 / RDC1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P
Unconjugated
50 µg/$440
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa100-150) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Horse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa311-360) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
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ACKR3 / CXCR7 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-P
Unconjugated
100 µg/$962
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ACKR3 / CXCR7 Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$941
ACKR3 / CXCR7 Antibody - Western blot of CXCR-7 antibody
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (290-370 aa, C-terminal) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ACKR3 / CXCR7 Antibody - Formalin-fixed and paraffin-embedded human testis tissue reacted with CXCR7 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa330-358) Antibody
Mouse, Human
IHC, WB
Unconjugated
400 µl/$393
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ACKR3 / CXCR7 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$890
ACKR3 / CXCR7 Antibody - CMKOR1 Antibody western blot of U251 cell line lysates (35 ug/lane). The CMKOR1 antibody detected the CMKOR1 protein (arrow).
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa333-362) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µg/$341
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ACKR3 / CXCR7 Mouse anti-Human Monoclonal (PerCP) (11n55) Antibody
Human
Flo
PerCP Conjugated
100 Tests/$941
Select
ACKR3 / CXCR7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$386
Select
ACKR3 / CXCR7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IP, WB
Unconjugated
100 µg/$331
Select
ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa333-362) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
Select
ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa333-362) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
Select
ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa333-362) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
Select
ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa333-362) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa333-362) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (aa333-362) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
ACKR3 / CXCR7 Antibody - Peptide - + Immunofluorescence analysis of COS-7 cells, using CXCR7 antibody.
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
ACKR3 / CXCR7 Antibody - Immunohistochemical analysis of GPR159 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
ACKR3 / CXCR7 Antibody - 1:100 staining human brain carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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ACKR3 / CXCR7 Rabbit anti-Human Polyclonal (Ala356) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
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ACKR3 / CXCR7 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
Viewing 1-25 of 43 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).