ACKR3 / CXCR7

atypical chemokine receptor 3

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

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Products

ELISA Kits (8)

Type

Custom (2)

Sandwich (6)

Target

ACKR3 / CXCR7 (8)

Reactivity

Human (4)

Mouse (1)

Rat (2)

Dog (1)

Format

96-Well Strip Plate (8)

Publications

No (8)

Sample Type

Cell Lysates (1)

Plasma (6)

Serum (6)

Tissue Homogenates (3)

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Mouse ACKR3 / CXCR7 (Sandwich ELISA) ELISA Kit - LS-F20361

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human ACKR3 / CXCR7 (Sandwich ELISA) ELISA Kit - LS-F7336

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$798

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Human ACKR3 / CXCR7 (Sandwich ELISA) ELISA Kit - LS-F11260

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat ACKR3 / CXCR7 (Sandwich ELISA) ELISA Kit - LS-F32202

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human ACKR3 / CXCR7 (Sandwich ELISA) ELISA Kit - LS-F36252

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat ACKR3 / CXCR7 (Custom ELISA) ELISA Kit - LS-F20360

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Dog ACKR3 / CXCR7 (Custom ELISA) ELISA Kit - LS-F20362

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human ACKR3 / CXCR7 (Sandwich ELISA) ELISA Kit - LS-F26917

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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