ACKR3 / CXCR7

atypical chemokine receptor 3

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

ACKR3 / CXCR7 (5)

Publications

No (5)

Tag

6His-SUMO, N-terminus (2)

GST (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human ACKR3 / CXCR7 Protein (Recombinant GST) (Full Length) - LS-G34628

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.9 kDa

Price:

2 µg/$439

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ACKR3 / CXCR7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101650

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.3 kDa

Price:

100 µg/$494

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Human ACKR3 / CXCR7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76007

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.3 kDa

Price:

20 µg/$150

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Human ACKR3 / CXCR7 Protein (Recombinant 6His-SUMO, N-terminus) - LS-G56196

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ACKR3 / CXCR7 Protein (Recombinant 6His-SUMO, N-terminus) (Full Length) - LS-G136389

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Molecular Weight:

57.5kDa

Price:

100 µg/$1,801; 20 µg/$1,247

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