ACO1 / Aconitase

Aconitase 1

IRP1 / Aconitase is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants

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Products

ELISA Kits (11)

Type

Custom (1)

Sandwich (9)

Sandwich CLIA (1)

Target

ACO1 / Aconitase (11)

Reactivity

Human (5)

Mouse (1)

Rat (2)

Bovine (1)

Chicken (1)

Monkey (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (9)

Publications

No (11)

Sample Type

Plasma (6)

Serum (6)

Tissue Homogenates (3)

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Human ACO1 / Aconitase (Sandwich ELISA) ELISA Kit - LS-F33124

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Bovine ACO1 / Aconitase (Custom) ELISA Kit - LS-F65243

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Price:

1 Plate/$669

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Human ACO1 / Aconitase (Sandwich ELISA) ELISA Kit - LS-F66570

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 U/l

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Chicken ACO1 / Aconitase (Sandwich ELISA) ELISA Kit - LS-F65838

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.78 - 50 ng/ml

Price:

1 Plate/$783

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Mouse ACO1 / Aconitase (Sandwich ELISA) ELISA Kit - LS-F65587

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.625 - 40 ng/ml

Price:

1 Plate/$669

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Rat ACO1 / Aconitase (Sandwich ELISA) ELISA Kit - LS-F66825

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.6 - 1000 U/l

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat ACO1 / Aconitase (Sandwich ELISA) ELISA Kit - LS-F8597

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$783

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Human ACO1 / Aconitase (Sandwich ELISA) ELISA Kit - LS-F6796

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

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Human ACO1 / Aconitase (Sandwich ELISA) ELISA Kit - LS-F20897

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human ACO1 / Aconitase (CLIA) ELISA Kit - LS-F29317

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Monkey ACO1 / Aconitase (Sandwich ELISA) ELISA Kit - LS-F40761

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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