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ACO2 / Aconitase 2

aconitase 2, mitochondrial

ACO2 / Aconitase 2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

Gene Name: aconitase 2, mitochondrial
Synonyms: ACO2, ACONM, Aconitase 2, Aconitase 2, mitochondrial, Citrate hydro-lyase, ICRD
Target Sequences: NM_001098 NP_001089.1 Q99798

Publications (1)

1
PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1. Goo CK, Lim HY, Ho QS, Too HP, Clement MV, Wong KP. PloS one. 2012 7:e45806. [PubMed:23049865] [PMC:PMC3458951]

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
ACO2 / Aconitase 2 (7)
No (7)
GST (1)
GST, N-terminus (1)
His,N-terminus + GST (1)
His-GST (1)
Myc-DDK (Flag) (3)
Human (5)
Mouse (1)
293T Cells (1)
Baculovirus (1)
HEK 293 Cells (2)
Insect Cells (1)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (2)
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Insect Cells
His,N-terminus + GST
Less than 1.0 EU/µg protein (determined by LAL method).
110 kDa
50 µg/$854
ACO2 / Aconitase 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
85.43 kDa
100 µg/$494
ACO2 / Aconitase 2 Protein - Purified recombinant protein ACO2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
82.4 kDa
20 µg/$1,107
ACO2 / Aconitase 2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ACO2 / Aconitase 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
85.43 kDa
20 µg/$150
ACO2 / Aconitase 2 Protein - 12.5% SDS-PAGE of human ACO2 stained with Coomassie Blue
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Wheat Germ Extract
GST
111.8 kDa
10 µg/$479; 25 µg/$670
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Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
110 kDa
100 µg/$843
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).