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ACVR1B / ALK4

activin A receptor, type IB

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

Gene Name: activin A receptor, type IB
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: ACVR1B, ACTR-IB, ACTRIB, ALK4, Activin receptor type IB, Activin A Receptor Type IB, Activin A receptor, type IB, Activin receptor-like kinase 4, ACVRLK4, ALK-4, Activin receptor type-1B, SKR2-2, SKR2
Target Sequences: NM_004302 NP_004293.1 P36896

Publications (1)

1
The Dynamics of TGF-ß Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery. Miller DSJ, Bloxham RD, Jiang M, Gori I, Saunders RE, Das D, Chakravarty P, Howell M, Hill CS. Cell reports. 2018 November;25:1841-1855. [Full Text Article] [PubMed:30428352] Related Antibodies: LS-B2695.

☰ Filters
Products
Proteins (14)
Over-Expression Lysate (2)
Recombinant (12)
ACVR1B / ALK4 (14)
No (14)
6His, C-terminus (3)
6His, N-terminus (1)
Fc, C-terminus (3)
GST (1)
GST, N-terminus (1)
GST, N-terminus + His, C-terminus (1)
His (2)
Myc-DDK (Flag) (2)
Human (9)
Mouse (3)
Rat (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Human Cells (2)
Mammalian Cells (3)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (6)
Biologically active (1)
ACVR1B / ALK4 Protein - Recombinant Activin A Receptor Type I B By SDS-PAGE
Select
E. coli
His
12.9 kDa
10 µg/$273; 50 µg/$390; 100 µg/$622; 200 µg/$777; 1 mg/$1,840; 500 µg/$1,398; 5 mg/$2,801; 2 mg/$2,023
ACVR1B / ALK4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ACVR1B / ALK4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
56.81 kDa
100 µg/$494
ACVR1B / ALK4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
56.81 kDa
20 µg/$150
ACVR1B / ALK4 Protein
Select
E. coli
GST, N-terminus + His, C-terminus
84.8 kDa
50 µg/$419
ACVR1B / ALK4 Protein - 12.5% SDS-PAGE of human ACVR1B stained with Coomassie Blue
Select
Wheat Germ Extract
GST
81.29 kDa
10 µg/$479; 25 µg/$670
ACVR1B / ALK4 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
43 kDa
10 µg/$265; 20 µg/$291; 50 µg/$315
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.7 kDa
10 µg/$266; 50 µg/$339
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.4 kDa
100 µg/$721
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.5 kDa
10 µg/$248; 50 µg/$288
ACVR1B / ALK4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
12.46 kDa
50 µg/$313; 10 µg/$259; 1 mg/$1,470; 500 µg/$1,025
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.7kD
10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.46kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
Select
E. coli
His
21.7 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).