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ACVR2 / ACVR2A

activin A receptor, type IIA

ACVR2 / ACVR2A is a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Gene Name: activin A receptor, type IIA
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: ACVR2A, ACTRIIA, Activin receptor type IIA, ACTRII, Activin A receptor type II, Activin receptor type-2A, ACTR-IIA, Activin A receptor, type II, Activin A receptor, type IIA, ACVR2
Target Sequences: NM_001616 NP_001607.1 P27037

Publications (1)

1
Detection of Sotatercept (ACE-011) in human serum by SAR-PAGE and western single blotting. Christian Reichel, Letizia Farmer, Günter Gmeiner, Katja Walpurgis, Mario Thevis. Drug testing and analysis. 2018 June;10:927-937. [Full Text Article] [PubMed:29193906]

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Antibodies (81)
Primary (81)
ACVR2 / ACVR2A (81)
Human (51)
Mouse (39)
Rat (15)
Bovine (20)
Cow (16)
Dog (3)
Goat (3)
Guinea pig (3)
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IHC (18)
IHC-P (10)
WB (78)
Flo (1)
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IP (1)
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Peptide-ELISA (2)
rabbit (71)
mouse (8)
goat (2)
Product Group
IHCPlus (2)
PathPlus Neuro (3)
IgG (20)
IgG1 (6)
IgG2a (2)
monoclonal mc (8)
polyclonal pc (73)
12K5 (1)
OTI1F2 (2)
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Unconjugated (36)
aa20-135 (24)
aa192-325 (8)
aa326-485 (8)
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C-Terminus (4)
Extracellular Domain (4)
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No (81)
ACVR2 / ACVR2A Antibody - Anti-ACVR2A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroscience
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa2-29) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$440
ACVR2 / ACVR2A Antibody - Anti-ALK-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Neuroscience
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (Extracellular Domain) Antibody
Human
ELISA, WB
Unconjugated
500 µg/$1,089
ACVR2 / ACVR2A Antibody - Mouse Acvr2a Antibody western blot of mouse kidney tissue lysates (35 ug/lane). The Acvr2a antibody detected the Acvr2a protein (arrow).
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa22-49) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
ACVR2 / ACVR2A Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa20-140) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (Extracellular Domain) (APC) (12K5) Antibody
Human
Flo
APC Conjugated
100 Tests/$896
ACVR2 / ACVR2A Antibody - Western blot analysis of lysates from rat kidney, using ACTR-IIA antibody.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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ACVR2 / ACVR2A Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, IHC, IP, Neut, WB
Unconjugated
100 µg/$962
ACVR2 / ACVR2A Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using ACVR2A Polyclonal Antibody at dilution of 1:20.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ACVR2 / ACVR2A Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa45-305) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACVR2 / ACVR2A Antibody - 1:100 staining human urothelial carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ACVR2 / ACVR2A Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa267-513) Antibody
Mouse, Bovine, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
ACVR2 / ACVR2A Antibody - Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-ACVR2A mouse monoclonal antibody.This figure shows negative staining. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (OTI1F2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ACVR2 / ACVR2A Antibody - Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-ACVR2A mouse monoclonal antibody.This figure shows negative staining. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (Carrier-free) (OTI1F2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ACVR2 / ACVR2A Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using ACVR2A Polyclonal Antibody at dilution of 1:20.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ACVR2 / ACVR2A Antibody - Immunohistochemistry of paraffin-embedded mouse kidney tissue.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ACVR2 / ACVR2A Antibody - Immunohistochemistry of paraffin-embedded human skin using antibody at 1:100 dilution.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa20-140) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
ACVR2 / ACVR2A Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-ACVR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (OTI5D1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ACVR2 / ACVR2A Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-ACVR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (Carrier-free) (OTI5D1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ACVR2 / ACVR2A Antibody - ACVR2A was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- ACVR2A Antigen Affinity purified polyclonal antibody
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ACVR2 / ACVR2A Antibody
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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ACVR2 / ACVR2A Rabbit anti-Mouse Polyclonal (aa22-49) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).