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ACVR2 / ACVR2A

activin A receptor, type IIA

ACVR2 / ACVR2A is a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Gene Name: activin A receptor, type IIA
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: ACVR2A, ACTRIIA, Activin receptor type IIA, ACTRII, Activin A receptor type II, Activin receptor type-2A, ACTR-IIA, Activin A receptor, type II, Activin A receptor, type IIA, ACVR2
Target Sequences: NM_001616 NP_001607.1 P27037

Publications (1)

1
Detection of Sotatercept (ACE-011) in human serum by SAR-PAGE and western single blotting. Christian Reichel, Letizia Farmer, Günter Gmeiner, Katja Walpurgis, Mario Thevis. Drug testing and analysis. 2018 June;10:927-937. [Full Text Article] [PubMed:29193906]

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Products
Proteins (17)
Over-Expression Lysate (2)
Recombinant (15)
ACVR2 / ACVR2A (17)
No (17)
6His, C-terminus (2)
Fc, C-terminus (1)
Fc/6His,C-terminus (1)
Fc/His,C-terminus (1)
Fc-6His, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (5)
His,C-terminus (1)
His-GST (1)
Myc-DDK (Flag) (2)
Bovine (2)
Human (10)
Mouse (4)
293T Cells (1)
E. coli (5)
HEK 293 Cells (3)
Human Cells (4)
Mammalian Cells (2)
Wheat Germ Extract (2)
Purified (6)
Low endotoxin level (8)
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.35kD
10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157
ACVR2 / ACVR2A Protein - 12.5% SDS-PAGE of human ACVR2A stained with Coomassie Blue
Select
Wheat Germ Extract
GST
84.2 kDa
2 µg/$439
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.8 kDa
100 µg/$793; 1 mg/$4,191
ACVR2 / ACVR2A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
57.85 kDa
20 µg/$150
ACVR2 / ACVR2A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
57.85 kDa
100 µg/$494
ACVR2 / ACVR2A Protein - Recombinant Activin A Receptor Type II A By SDS-PAGE
Select
E. coli
His
15.0 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
ACVR2 / ACVR2A Protein - Recombinant Activin A Receptor Type II A By SDS-PAGE
Select
E. coli
His
16.8 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
Select
E. coli
His
19.6 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
ACVR2 / ACVR2A Protein - Recombinant Activin A Receptor Type II A By SDS-PAGE
Select
E. coli
His-GST
40.5 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
ACVR2 / ACVR2A Protein - Recombinant Activin A Receptor Type II A By SDS-PAGE
Select
E. coli
His
15.0 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
ACVR2 / ACVR2A Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.2kD
10 µg/$248; 50 µg/$321; 500 µg/$785; 1 mg/$1,021
Select
Mammalian Cells
Fc/6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.2 kDa
10 µg/$248; 50 µg/$317
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.35 kDa
10 µg/$262; 50 µg/$361
Select
HEK 293 Cells
Fc/His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.4 kDa
200 µg/$1,148
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40.0 kDa
200 µg/$1,148
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
14.9 kDa
100 µg/$793; 1 mg/$4,191
Viewing 1-17 of 17 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).