ACY1 / Aminoacylase 1

aminoacylase 1

ACY1 / Aminoacylase 1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

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Products

Proteins (18)

Type

Over-Expression Lysate (8)

Recombinant (10)

Target

ACY1 / Aminoacylase 1 (18)

Publications

No (18)

Tag

6His, N-terminus (1)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His (4)

His-S (1)

Myc-DDK (Flag) (9)

Species

Human (12)

Mouse (2)

Source

293T Cells (4)

Baculovirus (1)

E. coli (5)

HEK 293 Cells (5)

Human Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

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Human ACY1 / Aminoacylase 1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64922

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.7 kDa

Price:

20 µg/$1,107

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Human ACY1 / Aminoacylase 1 Protein (Recombinant His) (Met1-Ser408) - LS-G97125

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.3 kDa

Price:

50 µg/$721

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Mouse ACY1 / Aminoacylase 1 Protein (Recombinant His) (Met1-Ser408) - LS-G98044

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45 kDa

Price:

50 µg/$721

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Human ACY1 / Aminoacylase 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74480

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.6 kDa

Price:

20 µg/$150

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Human ACY1 / Aminoacylase 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74477

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.7 kDa

Price:

20 µg/$150

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Human ACY1 / Aminoacylase 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74478

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38 kDa

Price:

20 µg/$150

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Human ACY1 / Aminoacylase 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74479

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.1 kDa

Price:

20 µg/$150

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ACY1 / Aminoacylase 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123049

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.7 kDa

Price:

100 µg/$494

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ACY1 / Aminoacylase 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130913

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.6 kDa

Price:

100 µg/$494

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ACY1 / Aminoacylase 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130896

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.1 kDa

Price:

100 µg/$494

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ACY1 / Aminoacylase 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130890

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38 kDa

Price:

100 µg/$494

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Human ACY1 / Aminoacylase 1 Protein (Recombinant DDK,C-terminus) - LS-G142474

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

45.7 kDa

Price:

20 µg/$677

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Human ACY1 / Aminoacylase 1 Protein (Recombinant His-S) (aa2-408) - LS-G24740

Source:

E. coli

Tag:

His-S

Molecular Weight:

49.5 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human ACY1 / Aminoacylase 1 Protein (Recombinant GST) (Full Length) - LS-G27356

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.62 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ACY1 / Aminoacylase 1 Protein (Recombinant 6His, N-terminus) (Thr2-Ser408) - LS-G26484

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

48 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human ACY1 / Aminoacylase 1 Protein (Recombinant GST, N-terminus) (aa1-408) - LS-G56903

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ACY1 / Aminoacylase 1 Protein (Recombinant His) - LS-G880

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Mouse ACY1 / Aminoacylase 1 Protein (Recombinant His) - LS-G3344

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$739; 4 µg/$261

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