ADAM10

ADAM metallopeptidase domain 10

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

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Antibodies (52)

ELISA Kits (20)

Proteins (6)

Type

Competitive EIA (1)

Custom (4)

Over-Expression Lysate (3)

Primary (52)

Recombinant (3)

Sandwich (13)

Sandwich CLIA (2)

Target

ADAM10 (78)

Reactivity

Human (49)

Mouse (19)

Rat (21)

Bovine (6)

Chicken (1)

Monkey (2)

Pig (2)

Porcine (1)

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Application

IHC (15)

IHC-P (5)

WB (44)

Flo (2)

ELISA (11)

ICC (2)

IF (7)

Peptide-ELISA (1)

Host

rabbit (47)

mouse (3)

goat (1)

rabbit-new zealand white (1)

Product Group

IHCPlus (1)

PathPlus Neuro (1)

Isotype

IgG (25)

IgG1 (1)

IgG2b (2)

Clonality

monoclonal mc (3)

polyclonal pc (49)

Clone

163003 (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (18)

APC (2)

APC Conjugated (4)

Biotin Conjugated (5)

CF Conjugated (1)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (4)

Preservative Free (2)

Unconjugated (24)

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Epitope

aa218-445 (8)

aa420-641 (8)

170-250 aa, Internal (1)

Internal (1)

aa214-672 (1)

aa390-440 (1)

aa612-627 (1)

Publications

No (77)

Yes (1)

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Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (12)

Serum (12)

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Tag

8His, N-terminus (1)

GST, N-terminus (1)

His (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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ADAM10 Antibody LS-C497146

Antibody:

ADAM10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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Human ADAM10 (Sandwich ELISA) ELISA Kit - LS-F4856

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

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Human ADAM10 (Sandwich ELISA) ELISA Kit - LS-F23768

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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IHC-plus™ ADAM10 Antibody LS-B16841

(4.0) Rating

Antibody:

ADAM10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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ADAM10 Antibody LS-C289

Antibody:

ADAM10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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Mouse ADAM10 (Sandwich ELISA) ELISA Kit - LS-F9938

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

Select

Rat ADAM10 (Sandwich ELISA) ELISA Kit - LS-F6604

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$715

Select

ADAM10 Antibody (aa214-672) LS-C122598

Antibody:

ADAM10 Goat anti-Human Polyclonal (aa214-672) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

1 mg/$990

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PathPlus™ ADAM10 Antibody (aa420-641) LS-B13920

Neuroscience

(5.0) Rating

Antibody:

ADAM10 Rabbit anti-Human Polyclonal (aa420-641) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

Human ADAM10 (Sandwich ELISA) ELISA Kit - LS-F13052

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

Mouse ADAM10 (Sandwich ELISA) ELISA Kit - LS-F55894

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

ADAM10 Antibody LS-C404444

Antibody:

ADAM10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

ADAM10 Antibody (170-250 aa, Internal) LS-C380447

Antibody:

ADAM10 Rabbit anti-Human Polyclonal (170-250 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

ADAM10 Antibody LS-C662652

Antibody:

ADAM10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

ADAM10 Antibody (CF) LS-C124902

Antibody:

ADAM10 Mouse anti-Human Monoclonal (CF) Antibody

Reactivity:

Human

Applications:

Flo

Format:

CF Conjugated

Price:

100 Tests/$755

Select

Mouse ADAM10 (Sandwich ELISA) ELISA Kit - LS-F38923

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

18.8 - 1200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$741

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Rat ADAM10 Protein (Recombinant His) (aa218-445) - LS-G12760

Source:

E. coli

Tag:

His

Molecular Weight:

26.5 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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ADAM10 Antibody LS-C375148

Antibody:

ADAM10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

ADAM10 Antibody (Biotin) LS-C375150

Antibody:

ADAM10 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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ADAM10 Antibody (HRP) LS-C543315

Antibody:

ADAM10 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, IHC, WB

Format:

HRP Conjugated

Price:

100 µl/$1,023

Select

ADAM10 Antibody (Biotin) LS-C523182

Antibody:

ADAM10 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,023

Select

ADAM10 Antibody (FITC) LS-C533226

Antibody:

ADAM10 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$1,023

Select

ADAM10 Antibody (APC) LS-C514951

Antibody:

ADAM10 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, IHC, WB

Format:

APC Conjugated

Price:

100 µl/$1,023

Select

ADAM10 Antibody (PE) LS-C651424

Antibody:

ADAM10 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, IHC, WB

Format:

PE Conjugated

Price:

100 µl/$1,023

• HRP
• Biotin
• FITC
• APC
• PE

• HRP
• Biotin
• FITC
• More...
  • APC
  • PE

Select

ADAM10 Antibody LS-C813361

Antibody:

ADAM10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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