ADAM10

ADAM metallopeptidase domain 10

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

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Products

ELISA Kits (20)

Type

Competitive EIA (1)

Custom (4)

Sandwich (13)

Sandwich CLIA (2)

Target

ADAM10 (20)

Reactivity

Human (6)

Mouse (4)

Rat (4)

Chicken (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (18)

Publications

No (19)

Yes (1)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (12)

Serum (12)

Tissue Homogenates (7)

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Human ADAM10 (Sandwich ELISA) ELISA Kit - LS-F4856

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

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Human ADAM10 (Sandwich ELISA) ELISA Kit - LS-F23768

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse ADAM10 (Sandwich ELISA) ELISA Kit - LS-F9938

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

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Rat ADAM10 (Sandwich ELISA) ELISA Kit - LS-F6604

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$715

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Mouse ADAM10 (Sandwich ELISA) ELISA Kit - LS-F55894

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human ADAM10 (Sandwich ELISA) ELISA Kit - LS-F13052

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse ADAM10 (Sandwich ELISA) ELISA Kit - LS-F38923

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

18.8 - 1200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$741

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Rat ADAM10 (Custom ELISA) ELISA Kit - LS-F15177

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Pig ADAM10 (Custom ELISA) ELISA Kit - LS-F15178

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Mouse ADAM10 (Custom ELISA) ELISA Kit - LS-F15179

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Bovine ADAM10 (Custom ELISA) ELISA Kit - LS-F15180

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Rat ADAM10 (CLIA) ELISA Kit - LS-F26524

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

6.86 - 5000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$911

Select

Human ADAM10 (Sandwich ELISA) ELISA Kit - LS-F26684

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

250 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Human ADAM10 (Sandwich ELISA) ELISA Kit - LS-F35973

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat ADAM10 (Competitive EIA) ELISA Kit - LS-F27873

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

50 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Human ADAM10 (CLIA) ELISA Kit - LS-F29256

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Chicken ADAM10 (Sandwich ELISA) ELISA Kit - LS-F40687

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

3.125 - 200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Monkey ADAM10 (Sandwich ELISA) ELISA Kit - LS-F40689

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Porcine ADAM10 (Sandwich ELISA) ELISA Kit - LS-F40690

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Rabbit ADAM10 (Sandwich ELISA) ELISA Kit - LS-F40691

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

2.5 - 160 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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