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ADAM12 is a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form.
Gene Name: | ADAM metallopeptidase domain 12 |
Family/Subfamily: | Protease , Metallopeptidase M12B |
Synonyms: | ADAM12, ADAM 12, MCMPMltna, MCMP, MLTN, Meltrin-alpha, MLTNA |
Target Sequences: | NM_003474 NP_003465.3 O43184 |
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