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ADAM12

ADAM metallopeptidase domain 12

ADAM12 is a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form.

Gene Name: ADAM metallopeptidase domain 12
Family/Subfamily: Protease , Metallopeptidase M12B
Synonyms: ADAM12, ADAM 12, MCMPMltna, MCMP, MLTN, Meltrin-alpha, MLTNA
Target Sequences: NM_003474 NP_003465.3 O43184

Publications (1)

1
Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma. T Kauttu, H Mustonen, S Vainionpää, L Krogerus, I Ilonen, J Räsänen, J Salo, P Puolakkainen. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2017 January;19:58-66. [Full Text Article] [PubMed:27026568] Related Antibodies: LS-B2756.

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Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
ADAM12 (7)
No (7)
10His, N-terminus + Myc, C-terminus (1)
GST (1)
GST, N-terminus (1)
His, C-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (5)
Mouse (1)
293T Cells (1)
Baculovirus (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (1)
ADAM12 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Baculovirus
10His, N-terminus + Myc, C-terminus
100 µg/$1,067; 20 µg/$447; 1 mg/$1,988
ADAM12 Protein - 12.5% SDS-PAGE of human ADAM12 stained with Coomassie Blue
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Wheat Germ Extract
GST
106.8 kDa
10 µg/$479; 25 µg/$670
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HEK 293 Cells
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
55.2 kDa
20 µg/$502; 100 µg/$1,148
ADAM12 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
77.6 kDa
20 µg/$150
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HEK 293 Cells
Myc-DDK (Flag)
77.6 kDa
100 µg/$494
ADAM12 Protein - Recombinant A Disintegrin And Metalloprotease 12 By SDS-PAGE
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E. coli
His-T7
31.3 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).