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ADAM22

ADAM metallopeptidase domain 22

ADAM22 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.

Gene Name: ADAM metallopeptidase domain 22
Family/Subfamily: Protease Non Catalytic , Metallopeptidase Non-catalytic
Synonyms: ADAM22, ADAM 22, Mdc2 beta, MDC2
Target Sequences: NM_016351 NP_057435.2 Q9P0K1

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Proteins (2)
Recombinant (2)
ADAM22 (2)
No (2)
GST (1)
His-T7 (1)
Human (2)
E. coli (1)
Wheat Germ Extract (1)
Purified (1)
ADAM22 Protein - 12.5% SDS-PAGE of human ADAM22 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.9 kDa
10 µg/$479; 25 µg/$670
ADAM22 Protein - Recombinant A Disintegrin And Metalloprotease 22 By SDS-PAGE
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E. coli
His-T7
27.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).