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ADAM9 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene.
Gene Name: | ADAM metallopeptidase domain 9 |
Family/Subfamily: | Protease , Metallopeptidase M12B |
Synonyms: | ADAM9, ADAM 9, CORD9, ADAM metallopeptidase domain 9, MCMP, Meltrin-gamma, Cone rod dystrophy 9, KIAA0021, MDC9, Mltng, Myeloma cell metalloproteinase |
Target Sequences: | NM_003816 NP_003807.1 Q13443 |
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