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ADAMTS12 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.
Gene Name: | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Family/Subfamily: | Protease , Metallopeptidase M12B |
Synonyms: | ADAMTS12, ADAMTS-12, ADAM-TS12, ADAM-TS 12, PRO4389 |
Target Sequences: | NM_030955 NP_112217.2 P58397 |
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