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ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.
Gene Name: | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
Family/Subfamily: | Protease , Metallopeptidase M12B |
Synonyms: | ADAMTS5, Aggrecanase-2, ADAM-TS 11, ADAM-TS5, ADAMTS-11, ADAMTS11, ADAM-TS 5, ADAMTS-5, ADMP-2, ADMP2 |
Target Sequences: | NM_007038 NP_008969.2 Q9UNA0 |
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