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ADAMTS8 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.
Gene Name: | ADAM metallopeptidase with thrombospondin type 1 motif, 8 |
Family/Subfamily: | Protease , Metallopeptidase M12B |
Synonyms: | ADAMTS8, ADAM-TS 8, ADAM-TS8, ADAMTS-8, METH2 |
Target Sequences: | NM_007037 NP_008968.4 Q9UP79 |
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