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ADCK4

aarF domain containing kinase 4

ADCK4 is a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: aarF domain containing kinase 4
Family/Subfamily: Protein Kinase , ABC1
Synonyms: ADCK4, COQ8
Target Sequences: NM_024876 AAH13114.2 Q96D53

Publications (3)

1
Mutations in COQ8B (ADCK4) found in patients with steroid-resistant nephrotic syndrome alter COQ8B function. Vazquez Fonseca L, Doimo M, Calderan C, Desbats MA, Acosta MJ, Cerqua C, Cassina M, Ashraf S, Hildebrandt F, Sartori G, Navas P, Trevisson E, Salviati L. Human mutation. 2018 March;39:406-414. (Human) [Full Text Article] [PubMed:29194833] [PMC:PMC5838795] Related Antibodies: LS-C119206.
2
ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment. Eugen Widmeier, Seyoung Yu, Anish Nag, Youn Wook Chung, Makiko Nakayama, Lucía Fernández-Del-Río, Hannah Hugo, David Schapiro, Florian Buerger, Won-Il Choi, Martin Helmstädter, Jae-Woo Kim, Ji-Hwan Ryu, Min Goo Lee, Catherine F Clarke, Friedhelm Hildebrandt, Heon Yung Gee. Journal of the American Society of Nephrology : JASN. 2020 June;31:1191-1211. [Full Text Article] [PubMed:32381600] [PMC:PMC7269352] Related Antibodies: LS-C119206.
3
Identification of a common polymorphism in COQ8B acting as a modifier of thoracic aortic aneurysm severity. Benjamin J Landis, Dongbing Lai, Dong-Chuan Guo, Joel S Corvera, Muhammad T Idrees, Henry W Stadler, Christian Cuevas, Gavin U Needler, Courtney E Vujakovich, Dianna M Milewicz, Robert B Hinton, Stephanie M Ware. HGG advances. 2022 January;3: [Full Text Article] [PubMed:34917985] [PMC:PMC8670066] Related Antibodies: LS-C119206.

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
ADCK4 (6)
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GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (4)
Human (4)
293T Cells (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
ADCK4 Protein - 12.5% SDS-PAGE of human ADCK4 stained with Coomassie Blue
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Wheat Germ Extract
GST
82.3 kDa
2 µg/$439
ADCK4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
55.7 kDa
20 µg/$150
ADCK4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$150
ADCK4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
100 µg/$494
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HEK 293 Cells
Myc-DDK (Flag)
55.7 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).