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ADCY5 / Adenylate Cyclase 5 is a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
Gene Name: | adenylate cyclase 5 |
Family/Subfamily: | Adenylate cyclase , not assigned-Adenylate cyclase |
Synonyms: | ADCY5, Adenylate cyclase 5, Adenylate cyclase type V, AC5, Adenylyl cyclase 5, ATP pyrophosphate-lyase 5, Adenylate cyclase type 5, FDFM |
Target Sequences: | U65473 AAD00121.1 |
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