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ADGRE2 / EMR2
egf-like module containing, mucin-like, hormone receptor-like 2
ADGRE2 / EMR2 is a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
| Gene Name: | egf-like module containing, mucin-like, hormone receptor-like 2 |
| Family/Subfamily: | GPCR , Orphan-B |
| Synonyms: | ADGRE2, CD312 antigen, EMR2, EGF-like module receptor 2, CD312 |
| Target Sequences: | NM_013447 NP_038475.2 Q9UHX3 |
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