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ADGRE3 / EMR3 is a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms.
|Gene Name:||egf-like module containing, mucin-like, hormone receptor-like 3|
|Family/Subfamily:||GPCR , Orphan-B|
|Synonyms:||ADGRE3, EGF-like module receptor 3, EMR3|
|Target Sequences:||NM_032571 NP_115960.2 Q9BY15|
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