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Latrophilin-2 is an Orphan-B Receptor that binds alpha-latrotoxin, a potent presynaptic neurotoxin present in the venom of the black widow spider, in a Ca2+-independent manner. As with the other two latrophilins, it shares homology with lectin, olfactomedin, and transmembrane domains, and possesses variable C-termini and various alternative-splice sites. Latrophilin-2 is endoproteolytically cleaved at the end of the GPS domain, and the two subunits remain non-covalently linked as a heterodimer.
Gene Name: | latrophilin 2 |
Family/Subfamily: | GPCR , Orphan-B |
Synonyms: | ADGRL2, Cl2aa, CIRL2, CL2, Latrophilin 1, Latrophilin-2, Lectomedin-1, Latrophilin 2, Latrophilin homolog 2 (cow), KIAA0786, Beta-latrotoxin receptor, CIRL-2, Latrophilin homolog 1, Latrotoxin receptor 2, Latrotoxin receptor homolog 2, LEC1, LPHH1, LPHN2 |
Target Sequences: | NM_012302 NP_036434.1 O95490 |
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