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ADH1C encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.
Gene Name: | alcohol dehydrogenase 1C (class I), gamma polypeptide |
Synonyms: | ADH1C, Alcohol dehydrogenase 1C, ADH, gamma subunit, Aldehyde reductase, ADH3 |
Target Sequences: | NM_000669 NP_000660.1 P00326 |
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