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The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | alcohol dehydrogenase 1B (class I), beta polypeptide |
Synonyms: | ADH1B, Alcohol dehydrogenase 1B, ADH, beta subunit, Aldehyde reductase, ADH2 |
Target Sequences: | NM_000668 NP_000659.2 P00325 |
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