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ADH5 is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene.
Gene Name: | alcohol dehydrogenase 5 (class III), chi polypeptide |
Synonyms: | ADH5, Alcohol dehydrogenase 5, ADHX, Formaldehyde dehydrogenase, ADH-3, Alcohol dehydrogenase class-3, FALDH, GSH-FDH, GSNOR, FDH |
Target Sequences: | NM_000671 NP_000662.3 P11766 |
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