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ADM / Adrenomedullin

adrenomedullin

Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.

Gene Name: adrenomedullin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: ADM, Adrenomedullin, AM, Preproadrenomedullin
Target Sequences: NM_001124 NP_001115.1 P35318

Publications (2)

1
Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth. Akiko Nakayama, Kenneth Anthony Roquid, András Iring, Boris Strilic, Stefan Günther, Min Chen, Lee S Weinstein, Stefan Offermanns. The Journal of experimental medicine. 2023 Janurary;220: [Full Text Article] [PubMed:36374225] [PMC:PMC9665902] Related Antibodies: LS-B15534.
2
Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses. Sudikshya Paudel, Bangmin Liu, Magdalina J Cummings, Kelsey E Quinn, Fuller W Bazer, Kathleen M Caron, Xiaoqiu Wang. Biology of reproduction. 2021 October;105:876-891. [Full Text Article] [PubMed:34104954] [PMC:PMC8511665]

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Antibodies (105)
Primary (105)
ADM / Adrenomedullin (105)
Human (68)
Mouse (24)
Rat (41)
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Chimpanzee (3)
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rabbit (86)
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91-140 aa, Internal (1)
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ADM / Adrenomedullin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$801
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
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ADM / Adrenomedullin Rabbit anti-Mouse Polyclonal (aa1-50) Antibody
Mouse
ELISA
Unconjugated
400 µg/$860
ADM / Adrenomedullin Antibody - Adrenomedullin staining in human lung cancer tissue. Paraffin-embedded human lung cancer tissue is stained with Adrenomedullin antibody used at 1:200 dilution.
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$432
ADM / Adrenomedullin Antibody - Western blot of recombinant ADM / Adrenomedullin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADM / Adrenomedullin Rabbit anti-Mouse Polyclonal (aa24-171) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa1-52) Antibody
Human
ELISA
Unconjugated
400 µg/$941
ADM / Adrenomedullin Antibody - Western blot of recombinant ADM / Adrenomedullin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADM / Adrenomedullin Rabbit anti-Dog Polyclonal (aa31-187) Antibody
Dog, Rat, Human
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
ADM / Adrenomedullin Antibody - Western blot of recombinant ADM / Adrenomedullin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADM / Adrenomedullin Rabbit anti-Cow Polyclonal (aa35-171) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589
ADM / Adrenomedullin Antibody - Immunohistochemistry of paraffin-embedded human lung tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa45-92) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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ADM / Adrenomedullin Rabbit anti-Mouse Polyclonal (aa1-50) Antibody
Mouse
ICC, IHC
Unconjugated
50 µl/$860
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa69-96) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa69-96) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa69-96) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa69-96) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa69-96) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa69-96) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa1-52) Antibody
Human
IF, IHC
Unconjugated
50 µl/$941
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC
Unconjugated
50 µl/$860
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa153-185) Antibody
Human
ELISA, IHC
Unconjugated
50 µl/$941
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ADM / Adrenomedullin Guinea pig anti-Rat Polyclonal (aa1-6) Antibody
Rat
IF, IHC, IHC-Fr
Unconjugated
50 µl/$1,153
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ADM / Adrenomedullin Guinea pig anti-Rat Polyclonal (Concentrated) Antibody
Rat
IF, IHC, IHC-Fr
Unconjugated, Concentrated
50 µl/$875
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ADM / Adrenomedullin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$941
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).