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ADRB3

adrenoceptor beta 3

The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility; beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure; ADRB3 is also one of the molecular targets under active research in the treatment of obesity.

Gene Name: adrenoceptor beta 3
Family/Subfamily: GPCR , Adrenergic
Synonyms: ADRB3, Adrenoceptor beta 3, ADRB3R, Adrenaline beta 3 receptor, Adrenergic, beta-3-, receptor, Beta-3 adrenergic receptor, B3AR, Beta-3 adrenoceptor, Beta3-AR, Beta-3 adrenoreceptor, BETA3AR
Target Sequences: NM_000025 NP_000016.1 P13945

Publications (7)

1
Effects of beta3-adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomy. Kullmann FA, Limberg BJ, Artim DE, Shah M, Downs TR, Contract D, Wos J, Rosenbaum JS, de Groat WC. The Journal of pharmacology and experimental therapeutics. 2009 330:704-17. (IHC-P; Rat) [Full Text Article] [PubMed:19515967] [PMC:PMC2729793] Related Antibodies: LS-A4198.
2
ß-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder. Limberg BJ, Andersson KE, Aura Kullmann F, Burmer G, de Groat WC, Rosenbaum JS. Cell and tissue research. 2011 317:107-16. (ICC, IHC-P; Human) [Full Text Article] [PubMed:20953633] [PMC:PMC3113530] Related Antibodies: LS-A4198.
3
Urothelial beta-3 adrenergic receptors in the rat bladder. Kullmann FA, Downs TR, Artim DE, Limberg BJ, Shah M, Contract D, de Groat WC, Rosenbaum JS. Neurourology and urodynamics. 2011 30:144-50. (IHC-P; Rat) [Full Text Article] [PubMed:21046653] [PMC:PMC3395322] Related Antibodies: LS-A4198.
4
ß3-Adrenergic receptor blockade reduces mortality in endotoxin-induced heart failure by suppressing induced nitric oxide synthase and saving cardiac metabolism. Satoshi Kawaguchi, Motoi Okada, Eriko Ijiri, Daisuke Koga, Tsuyoshi Watanabe, Kentaro Hayashi, Yuta Kashiwagi, Satoshi Fujita, Naoyuki Hasebe. American journal of physiology. Heart and circulatory physiology. 2020 February;318:H283-H294. [Full Text Article] [PubMed:31834837] Related Antibodies: LS-C353880.
5
The expression of ß3-adrenoceptors and their function in the human prostate. Takahisa Suzuki, Atsushi Otsuka, Rikiya Matsumoto, Hiroshi Furuse, Seiichiro Ozono. The Prostate. 2016 Feburary;76:163-71. [Full Text Article] [PubMed:26768278] Related Antibodies: LS-A4198.
6
Beta-3 adrenergic receptor is expressed in acetylcholine-containing nerve fibers of the human urinary bladder: An immunohistochemical study. Ana Coelho, Tiago Antunes-Lopes, James Gillespie, Francisco Cruz. Neurourology and urodynamics. 2017 November;36:1972-1980. [Full Text Article] [PubMed:28185314] Related Antibodies: LS-A4198.
7
Expression and functional role of beta 3 -adrenoceptors in the human ureter. Matsumoto R, Otsuka A, Suzuki T, Shinbo H, Mizuno T, Kurita Y, Mugiya S, Ozono S. International journal of urology : official journal of the Japanese Urological Association. Oct;20:1007-14. [Full Text Article] [PubMed:23360304] Related Antibodies: LS-A4198.
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☰ Filters
Antibodies (26)
ELISA Kits (3)
Proteins (3)
Over-Expression Lysate (2)
Primary (26)
Recombinant (1)
Sandwich (3)
ADRB3 (32)
Human (23)
Mouse (11)
Rat (9)
IHC (5)
IHC-P (3)
WB (18)
ELISA (12)
ICC (1)
IF (1)
IP (1)
Peptide-ELISA (6)
rabbit (23)
mouse (1)
goat (2)
Product Group
GPCR Database Antibodies (2)
PathPlus Neuro (2)
IgG (17)
polyclonal pc (26)
96-Well Strip Plate (3)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Preservative Free (1)
Unconjugated (23)
C-Terminus (6)
220-300 aa, Internal (1)
Internal (1)
Leu291 (1)
N-Terminus (1)
aa1-408 (1)
aa216-249 (1)
aa250-299 (1)
aa255-289 (1)
aa379-390 (1)
aa5-16 (1)
No (30)
Yes (2)
Cell Lysates (1)
Tissue Homogenates (3)
GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
ADRB3 Antibody - Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
ADRB3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
ICC, IHC, IHC-P
Unconjugated
50 µg/$440
ADRB3 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
Fast Shipping
ADRB3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Select
ADRB3 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µl/$832
ADRB3 Antibody - Western blot analysis of Beta-3 Adrenergic Receptor expression in MCF7 (A); mouse kidney (B); rat liver (C) whole cell lysates.
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ADRB3 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
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ADRB3 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µl/$801
ADRB3 Antibody - Western blot analysis of lysates from K562 cells, using ADRB3 Antibody. The lane on the right is blocked with the synthesized peptide.
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ADRB3 Rabbit anti-Human Polyclonal (aa250-299) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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ADRB3 Mouse anti-Human Polyclonal (aa1-408) Antibody
Human
WB
Unconjugated
50 µg/$705
Select
ADRB3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$760
ADRB3 Antibody - All lanes: Anti-ADRB3 Antibody (C-Term) at 1:2000 dilution. Lane 1: mouse adipose tissue lysate. Lane 2: human brain lysate. Lane 3: HepG2 whole cell lysate. Lane 4: HL-60 whole cell lysate. Lane 5: 3T3-L1 whole cell lysate. Lane 6: NCI-H1299 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 44 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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ADRB3 Rabbit anti-Human Polyclonal (aa255-289) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
ADRB3 Antibody - Antibody (0.03 ug/ml) staining of Human Brain (Cerebral Cortex) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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ADRB3 Goat anti-Human Polyclonal (aa5-16) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ADRB3 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ADRB3 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ADRB3 Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer using ADRB3 Polyclonal Antibody at dilution of 1:60.
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ADRB3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
ADRB3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$801
Select
ADRB3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
ADRB3 Antibody - Western blot of AR-beta3 antibody
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ADRB3 Rabbit anti-Human Polyclonal (220-300 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ADRB3 Antibody - Western blot analysis of extracts from K562 cells, using ADRB3 antibody.
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ADRB3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
ADRB3 Antibody - Anti-ADRB3 Antibody (Center) at 1:1000 dilution + HL-60 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 44 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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ADRB3 Rabbit anti-Human Polyclonal (aa216-249) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
ADRB3 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ADRB3 Goat anti-Mouse Polyclonal (aa379-390) Antibody
Mouse
IHC-P, Peptide-ELISA
Unconjugated
100 µg/$401
ADRB3 Antibody - Immunofluorescent analysis of MCF-7 cells using ADRB3 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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ADRB3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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ADRB3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
ADRB3 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
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ADRB3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ADRB3 Antibody - Western blot of AR-3 (L291) pAb in extracts from K562 cells.
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ADRB3 Rabbit anti-Human Polyclonal (Leu291) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
ADRB3 Antibody - Western blot analysis of extracts of various cell lines.
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ADRB3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
ADRB3 Antibody - Anti-Adrb3 rabbit polyclonal antibody at 1:500 dilution. Lane A: K562 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 44 kDa. Observed band size: 35 kDa.
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ADRB3 Rabbit anti-Rat Polyclonal (Preservative Free) Antibody
Rat
IP, WB
Unconjugated, Preservative Free
100 µl/$412
Viewing 1-25 of 32 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).