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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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ADRB3
adrenoceptor beta 3
The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility; beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure; ADRB3 is also one of the molecular targets under active research in the treatment of obesity.
| Gene Name: | adrenoceptor beta 3 |
| Family/Subfamily: | GPCR , Adrenergic |
| Synonyms: | ADRB3, Adrenoceptor beta 3, ADRB3R, Adrenaline beta 3 receptor, Adrenergic, beta-3-, receptor, Beta-3 adrenergic receptor, B3AR, Beta-3 adrenoceptor, Beta3-AR, Beta-3 adrenoreceptor, BETA3AR |
| Target Sequences: | NM_000025 NP_000016.1 P13945 |
Publications (7)
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