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ADRB3

adrenoceptor beta 3

The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility; beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure; ADRB3 is also one of the molecular targets under active research in the treatment of obesity.

Gene Name: adrenoceptor beta 3
Family/Subfamily: GPCR , Adrenergic
Synonyms: ADRB3, Adrenoceptor beta 3, ADRB3R, Adrenaline beta 3 receptor, Adrenergic, beta-3-, receptor, Beta-3 adrenergic receptor, B3AR, Beta-3 adrenoceptor, Beta3-AR, Beta-3 adrenoreceptor, BETA3AR
Target Sequences: NM_000025 NP_000016.1 P13945

Publications (7)

1
Effects of beta3-adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomy. Kullmann FA, Limberg BJ, Artim DE, Shah M, Downs TR, Contract D, Wos J, Rosenbaum JS, de Groat WC. The Journal of pharmacology and experimental therapeutics. 2009 330:704-17. (IHC-P; Rat) [Full Text Article] [PubMed:19515967] [PMC:PMC2729793] Related Antibodies: LS-A4198.
2
ß-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder. Limberg BJ, Andersson KE, Aura Kullmann F, Burmer G, de Groat WC, Rosenbaum JS. Cell and tissue research. 2011 317:107-16. (ICC, IHC-P; Human) [Full Text Article] [PubMed:20953633] [PMC:PMC3113530] Related Antibodies: LS-A4198.
3
Urothelial beta-3 adrenergic receptors in the rat bladder. Kullmann FA, Downs TR, Artim DE, Limberg BJ, Shah M, Contract D, de Groat WC, Rosenbaum JS. Neurourology and urodynamics. 2011 30:144-50. (IHC-P; Rat) [Full Text Article] [PubMed:21046653] [PMC:PMC3395322] Related Antibodies: LS-A4198.
4
ß3-Adrenergic receptor blockade reduces mortality in endotoxin-induced heart failure by suppressing induced nitric oxide synthase and saving cardiac metabolism. Satoshi Kawaguchi, Motoi Okada, Eriko Ijiri, Daisuke Koga, Tsuyoshi Watanabe, Kentaro Hayashi, Yuta Kashiwagi, Satoshi Fujita, Naoyuki Hasebe. American journal of physiology. Heart and circulatory physiology. 2020 February;318:H283-H294. [Full Text Article] [PubMed:31834837] Related Antibodies: LS-C353880.
5
The expression of ß3-adrenoceptors and their function in the human prostate. Takahisa Suzuki, Atsushi Otsuka, Rikiya Matsumoto, Hiroshi Furuse, Seiichiro Ozono. The Prostate. 2016 Feburary;76:163-71. [Full Text Article] [PubMed:26768278] Related Antibodies: LS-A4198.
6
Beta-3 adrenergic receptor is expressed in acetylcholine-containing nerve fibers of the human urinary bladder: An immunohistochemical study. Ana Coelho, Tiago Antunes-Lopes, James Gillespie, Francisco Cruz. Neurourology and urodynamics. 2017 November;36:1972-1980. [Full Text Article] [PubMed:28185314] Related Antibodies: LS-A4198.
7
Expression and functional role of beta 3 -adrenoceptors in the human ureter. Matsumoto R, Otsuka A, Suzuki T, Shinbo H, Mizuno T, Kurita Y, Mugiya S, Ozono S. International journal of urology : official journal of the Japanese Urological Association. Oct;20:1007-14. [Full Text Article] [PubMed:23360304] Related Antibodies: LS-A4198.
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Proteins (3)
Over-Expression Lysate (2)
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ADRB3 (3)
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GST (1)
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293T Cells (1)
HEK 293 Cells (1)
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ADRB3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
43.3 kDa
100 µg/$494
ADRB3 Protein - 12.5% SDS-PAGE of human ADRB3 stained with Coomassie Blue
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Wheat Germ Extract
GST
69.9 kDa
2 µg/$439
ADRB3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
43.3 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).