ADRBK1 / GRK2

adrenergic, beta, receptor kinase 1

Beta-adrenergic receptor kinase (ADRBK1) phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. The ADRBK1 gene spans approximately 23 kb and is composed of 21 exons. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy.

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Products

Antibodies (66)

ELISA Kits (9)

Proteins (8)

Type

Cell-Based (2)

Cell-Based Phosphorylation (2)

Over-Expression Lysate (2)

Primary (66)

Recombinant (6)

Sandwich (5)

Target

ADRBK1 / GRK2 (83)

Reactivity

Human (67)

Mouse (50)

Rat (44)

Bat (7)

Bovine (11)

Chimpanzee (6)

Dog (8)

Gibbon (3)

Guinea pig (6)

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Horse (7)

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IHC (28)

IHC-P (14)

WB (57)

Flo (1)

ELISA (25)

ICC (2)

IF (4)

Peptide-ELISA (5)

Host

rabbit (57)

mouse (8)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (28)

IgG1 (4)

IgG1,k (1)

IgG2b (1)

Clonality

monoclonal mc (8)

polyclonal pc (58)

Clone

3F8 (2)

5D5 (1)

Format

96-Well Microplate (4)

96-Well Strip Plate (5)

APC (1)

APC Conjugated (1)

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HRP Conjugated (5)

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Unconjugated (47)

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Epitope

aa398-640 (8)

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aa35-84 (4)

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10-90 aa (1)

570-650 aa, C-terminal (1)

620-700 aa (1)

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Asp635 (1)

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Ser685 (1)

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aa14-63 (1)

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aa440-689 (1)

aa468-689 (1)

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No (82)

Yes (1)

Sample Type

Adherent Cell Cultures (4)

Plasma (5)

Serum (5)

Tissue Homogenates (4)

Tag

6His-SUMO, N-terminus (1)

GST (1)

His (1)

His-GST (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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ADRBK1 / GRK2 Antibody (phospho-Ser29) LS-C351799

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer29) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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Mouse ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F32085

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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IHC-plus™ ADRBK1 / GRK2 Antibody LS-B12295

(4.0) Rating

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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ADRBK1 / GRK2 Antibody (clone 3F8) LS-C169349

Antibody:

ADRBK1 / GRK2 Mouse anti-Human Monoclonal (3F8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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ADRBK1 / GRK2 Antibody (phospho-Ser685) LS-C199027

(4.0) Rating

(1) Publication(s)

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer685) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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ADRBK1 / GRK2 Antibody (aa633-660) LS-C98902

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (aa633-660) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse/Human/Rat ADRBK1 / GRK2 (Cell-Based ELISA) ELISA Kit - LS-F3075

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Human ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F9317

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

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Mouse/Human/Rat Phospho-ADRBK1 / GRK2 (Ser685) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1720

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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IHC-plus™ ADRBK1 / GRK2 Antibody (clone 5D5) LS-B225

(4.0) Rating

Antibody:

ADRBK1 / GRK2 Mouse anti-Human Monoclonal (5D5) Antibody

Reactivity:

Bovine, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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ADRBK1 / GRK2 Antibody (N-Terminus) LS-C358899

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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ADRBK1 / GRK2 Antibody LS-C193022

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$391; 100 µl/$489

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ADRBK1 / GRK2 Antibody (clone 3F8) LS-C758930

Antibody:

ADRBK1 / GRK2 Mouse anti-Human Monoclonal (3F8) Antibody

Reactivity:

Mouse, Rat, Primate, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

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ADRBK1 / GRK2 Antibody (Thr23) LS-C176319

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (Thr23) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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ADRBK1 / GRK2 Antibody (620-700 aa) LS-C381057

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (620-700 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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ADRBK1 / GRK2 Antibody (C-Terminus) LS-C351803

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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ADRBK1 / GRK2 Antibody (aa398-640, Biotin) LS-C686843

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (aa398-640) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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ADRBK1 / GRK2 Antibody LS-C812631

Antibody:

ADRBK1 / GRK2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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ADRBK1 / GRK2 Antibody LS-C665992

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

Mouse/Human/Rat ADRBK1 / GRK2 (Cell-Based ELISA) ELISA Kit - LS-F2028

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

Select

Human ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F32528

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human ADRBK1 / GRK2 Protein (Recombinant His) (Full Length) - LS-G22082

Source:

E. coli

Tag:

His

Molecular Weight:

29.7 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Mouse ADRBK1 / GRK2 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-689) - LS-G57608

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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ADRBK1 / GRK2 Antibody (phospho-Ser29) LS-C199026

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer29) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

ADRBK1 / GRK2 Antibody LS-C331619

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$287; 100 µl/$431

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