AF5Q31 / AFF4

AF4/FMR2 family, member 4

Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

AF5Q31 / AFF4 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human AF5Q31 / AFF4 Protein (Recombinant GST) (Full Length) - LS-G33264

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

66.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human AF5Q31 / AFF4 Protein (Recombinant GST, N-terminus) (aa1-108) - LS-G62236

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AF5Q31 / AFF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89963

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

20 µg/$215

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AF5Q31 / AFF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101217

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

100 µg/$710

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