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AGT / Angiotensinogen

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Gene Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: AGT, ANHU, Angiotensinogen, Pre-angiotensinogen, SERPINA8, Serpin A8
Target Sequences: NM_000029 NP_000020.1 P01019

Publications (6)

1
Reduced expression of angiotensin II and angiotensin receptor type 1 and type 2 in resistance arteries from nasal lesions in granulomatosis with polyangiitis (Wegener's granulomatosis). Dimitrijevic I, Rissler P, Luts L, Edvinsson L. Scandinavian journal of rheumatology. 2011 40:448-52. (ICC, IHC; Human) [PubMed:21936613]
2
Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy. Shababi M, Habibi J, Ma L, Glascock JJ, Sowers JR, Lorson CL. Journal of molecular and cellular cardiology. 2012 52:1074-82. (WB; Mouse) [PubMed:22285962] [PMC:PMC3327806]
3
Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study. Rahgozar S, Amirian T, Qi M, Shahshahan Z, Entezar-E-Ghaem M, Ghasemi Tehrani H, Miroliaei M, Krilis SA, Giannakopoulos B. PloS one. 2015 10:e0135905. (WB; Human) [Full Text Article] [PubMed:26312482] [PMC:PMC4552422] Related Antibodies: LS-C80597.
4
Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients. Urup T, Michaelsen SR, Olsen LR, Toft A, Christensen IJ, Grunnet K, Winther O, Broholm H, Kosteljanetz M, Issazadeh-Navikas S, Poulsen HS, Lassen U. Molecular oncology. 2016 October;10:1160-8. (Human) [Full Text Article] [PubMed:27262894] [PMC:PMC5423207] Related Antibodies: LS-B6575.
5
Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Sarah A Sapouckey, Lisa L Morselli, Guorui Deng, Chetan N Patil, Kirthikaa Balapattabi, Vanessa Oliveira, Kristin E Claflin, Javier Gomez, Nicole A Pearson, Matthew J Potthoff, Katherine N Gibson-Corley, Curt D Sigmund, Justin L Grobe. American journal of physiology. Regulatory, integrative and comparative physiology. 2020 May;318:R855-R869. [Full Text Article] [PubMed:32186897] [PMC:PMC7272763]
6
Persistent Renin-Angiotensin System Sensitization Months After Body Weight Recovery From Severe Food Restriction in Female Fischer Rats. Aline M A de Souza, Hong Ji, Xie Wu, Kathryn Sandberg, Crystal A West. Journal of the American Heart Association. 2020 July;9:e017246. [Full Text Article] [PubMed:32674648] [PMC:PMC7660733]
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☰ Filters
Products
Proteins (21)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (17)
AGT / Angiotensinogen (21)
No (21)
6His, C-terminus (2)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
8His, N-terminus (1)
GST (2)
GST, N-terminus (1)
His (2)
His, N-Terminal (4)
His,C-terminus (1)
His-GST (1)
His-S (2)
Myc-DDK (Flag) (3)
Human (14)
Mouse (3)
Rat (3)
293F Cells (2)
293T Cells (1)
E. coli (6)
HEK 293 Cells (6)
Human Cells (2)
Mammalian Cells (1)
Wheat Germ Extract (3)
Purified (7)
Low endotoxin level (4)
AGT / Angiotensinogen Protein - Recombinant Angiotensinogen By SDS-PAGE
Select
E. coli
His-S
56.1 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Select
HEK 293 Cells
8His, N-terminus
52.1 kDa
100 µg/$298
AGT / Angiotensinogen Protein - 12.5% SDS-PAGE of human AGT stained with Coomassie Blue
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Wheat Germ Extract
GST
79.09 kDa
10 µg/$479; 25 µg/$670
AGT / Angiotensinogen Protein - 12.5% SDS-PAGE of human AGT stained with Coomassie Blue
Select
Wheat Germ Extract
GST
77 kDa
10 µg/$479; 25 µg/$670
Select
HEK 293 Cells
6His, N-terminus
52.1 kDa
200 µl/$283
AGT / Angiotensinogen Protein - Purified recombinant protein AGT was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
49.7 kDa
20 µg/$1,107
AGT / Angiotensinogen Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
AGT / Angiotensinogen Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
AGT / Angiotensinogen Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
53.11 kDa
20 µg/$150
AGT / Angiotensinogen Protein - Eukaryotic Angiotensinogen (AGT) by SDS-PAGE
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293F Cells
His, N-Terminal
60kDa
10 µg/$277; 50 µg/$417; 200 µg/$832; 100 µg/$665; 1 mg/$1,920; 500 µg/$1,468; 5 mg/$2,905; 2 mg/$2,105
AGT / Angiotensinogen Protein - Eukaryotic Angiotensinogen (AGT) by SDS-PAGE
Select
293F Cells
His, N-Terminal
65kDa
10 µg/$276; 50 µg/$410; 200 µg/$820; 100 µg/$655; 1 mg/$1,902; 500 µg/$1,452; 5 mg/$2,864; 2 mg/$2,087
AGT / Angiotensinogen Protein
Select
E. coli
His, N-Terminal
52 kDa
10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50.8 kDa
100 µg/$721
AGT / Angiotensinogen Protein - Recombinant Angiotensinogen By SDS-PAGE
Select
E. coli
His-GST
76.7 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
AGT / Angiotensinogen Protein - Recombinant Angiotensinogen By SDS-PAGE
Select
E. coli
His-S
55.3 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
AGT / Angiotensinogen Protein - Recombinant Angiotensinogen By SDS-PAGE
Select
E. coli
His
24.5 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
AGT / Angiotensinogen Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
53.11 kDa
100 µg/$494
AGT / Angiotensinogen Protein
Select
HEK 293 Cells
His, N-Terminal
~53 kDa (55-65 kDa reducing conditions)
10 µg/$289; 200 µg/$646; 50 µg/$360
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
51 kDa
100 µg/$843
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
51.7kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
51.7 kDa
10 µg/$344; 50 µg/$584
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).