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AGXT2 is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants.
Gene Name: | alanine--glyoxylate aminotransferase 2 |
Synonyms: | AGXT2, AGT 2, AGT2, Beta-ALAAT II, D-AIBAT, DAIBAT |
Target Sequences: | NM_031900 NP_114106.1 Q9BYV1 |
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