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AHR

aryl hydrocarbon receptor

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Gene Name: aryl hydrocarbon receptor
Synonyms: AHR, Ah receptor, AH-receptor, Aryl hydrocarbon receptor, BHLHe76, Aromatic hydrocarbon receptor
Target Sequences: NM_001621 NP_001612.1 P35869

Publications (9)

1
Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten. Poland A, Glover E, Bradfield CA. Molecular pharmacology. 1991 39:20-6. [PubMed:1846218]
2
Baculovirus expression of the Ah receptor and Ah receptor nuclear translocater. Evidence for additional dioxin responsive element-binding species and factors required for signaling. Chan WK, Chu R, Jain S, Reddy JK, Bradfield CA. The Journal of biological chemistry. 1994 269:26464-71. [PubMed:7929368]
3
Possible involvement of aryl hydrocarbon receptor (AhR) in adult T-cell leukemia (ATL) leukemogenesis: constitutive activation of AhR in ATL. Hayashibara T, Yamada Y, Mori N, Harasawa H, Sugahara K, Miyanishi T, Kamihira S, Tomonaga M. Biochemical and biophysical research communications. 2003 300:128-34. [PubMed:12480531]
4
Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements. Minsavage GD, Vorojeikina DP, Gasiewicz TA. Archives of biochemistry and biophysics. 2003 412:95-105. [PubMed:12646272]
5
Critical enhancer region to which AhR/ARNT and Sp1 bind in the human CYP1B1 gene. Tsuchiya Y, Nakajima M, Yokoi T. Journal of biochemistry. 2003 133:583-92. [PubMed:12801909]
6
Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity. Fisher MT, Nagarkatti M, Nagarkatti PS. Toxicological sciences : an official journal of the Society of Toxicology. 2004 78:116-24. [PubMed:14718646]
7
Aryl hydrocarbon receptor is activated by glucose and regulates the thrombospondin-1 gene promoter in endothelial cells. Dabir P, Marinic TE, Krukovets I, Stenina OI. Circulation research. 2008 102:1558-65. [PubMed:18515748] [PMC:PMC2740473]
8
Interaction of aryl hydrocarbon receptor and NF-B subunit RelB in breast cancer is associated with interleukin-8 overexpression. Vogel CF, Li W, Wu D, Miller JK, Sweeney C, Lazennec G, Fujisawa Y, Matsumura F. Archives of biochemistry and biophysics. 2011 512:78-86. (IHC; Human) [PubMed:21640702] [PMC:PMC3135412]
9
Functional expression of aryl hydrocarbon receptor on mast cells populating human endometriotic tissues. Mariuzzi L, Domenis R, Orsaria M, Marzinotto S, Londero AP, Bulfoni M, Candotti V, Zanello A, Ballico M, Mimmi MC, Calcagno A, Marchesoni D, Di Loreto C, Beltrami AP, Cesselli D, Gri G. Laboratory investigation; a journal of technical methods and pathology. 2016 96:959-971. (IF; Human) [PubMed:27348627] [PMC:PMC5008463] Related Antibodies: LS-A3391.
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AHR Antibody - Anti-Aryl Hydrocarbon Receptor antibody IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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IHC-plus™ AHR Antibody (C-Terminus) LS-A3391
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(5.0) Rating
(1) Publication(s)
AHR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
AHR Antibody - Anti-Aryl Hydrocarbon Receptor antibody IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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IHC-plus™ AHR Antibody (Internal) LS-A3018
Fast Shipping
(4.0) Rating
AHR Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
AHR Antibody - Anti-Aryl Hydrocarbon Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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IHC-plus™ AHR Antibody (aa2-51) LS-B4900
(4.0) Rating
AHR Rabbit anti-Human Polyclonal (aa2-51) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
AHR Antibody - Anti-Aryl Hydrocarbon Receptor antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IHC-plus™ AHR Antibody (clone 3B9) LS-B6002
(4.0) Rating
AHR Mouse anti-Human Monoclonal (3B9) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
AHR Antibody - Anti-Aryl Hydrocarbon Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IHC-plus™ AHR Antibody (C-Terminus) LS-B164
(4.0) Rating
AHR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Guinea pig, Rat, Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
AHR Antibody - Anti-Aryl Hydrocarbon Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AHR Antibody (C-Terminus, Biotin) LS-C140969
AHR Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Guinea pig, Rat, Human
ICC, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
AHR Antibody - IHC staining of FFPE human esophagus squamous cancer with AHR antibody at 1ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
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AHR Antibody LS-C783005
AHR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, IHC-P, WB
Unconjugated
100 µg/$575
AHR Antibody - Immunohistochemical analysis of Ah Receptor (pS36) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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AHR Antibody (phospho-Ser36) LS-C354258
AHR Rabbit anti-Human Polyclonal (pSer36) Antibody
Chicken, Zebrafish, Rat, Rabbit, Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$315
AHR Antibody - Western blot of Ah Receptor antibody
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AHR Antibody (10-90 aa) LS-C381967
AHR Rabbit anti-Human Polyclonal (10-90 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
AHR Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue using AhR (Ab-36) antibody.
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AHR Antibody (p36) LS-C822098
AHR Rabbit anti-Human Polyclonal (p36) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
AHR Antibody - Anti-AHR antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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IHC-plus™ AHR Antibody (aa32-81) LS-B10220
(4.0) Rating
AHR Rabbit anti-Human Polyclonal (aa32-81) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
AHR Antibody - Western blot of AhR polyclonal antibody: Lane 1: MW marker; Lane 2: Rat liver lysate; Lane 3: Mouse liver lysate.
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AHR Antibody LS-C343830
AHR Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
IP, WB
Unconjugated
100 µl/$576
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AHR Antibody (aa555-582, FITC) LS-C251055
AHR Rabbit anti-Human Polyclonal (aa555-582) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
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AHR Antibody (aa555-582, PE) LS-C251057
AHR Rabbit anti-Human Polyclonal (aa555-582) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
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AHR Antibody (aa555-582, APC) LS-C251056
AHR Rabbit anti-Human Polyclonal (aa555-582) (APC) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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AHR Antibody (aa18-21, clone RPT9) LS-C63836
AHR Mouse anti-Mouse Monoclonal (aa18-21) (RPT9) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IP, WB
Unconjugated
100 µl/$842
AHR Antibody - AHR Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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AHR Antibody (aa555-582) LS-C156174
AHR Rabbit anti-Human Polyclonal (aa555-582) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
AHR Antibody - Placenta Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AHR Antibody (N-Terminus) LS-C31440
AHR Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
AHR Antibody - Anti-Aryl Hydrocarbon Receptor antibody IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
IHC-plus™ AHR Antibody (Internal) LS-A3017
Fast Shipping
(4.0) Rating
AHR Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
AHR Antibody - Anti-Aryl Hydrocarbon Receptor antibody IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
IHC-plus™ AHR Antibody (N-Terminus) LS-A3005
Fast Shipping
(4.0) Rating
AHR Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Select
AHR Antibody (APC) LS-C512427
AHR Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, IF, IP, WB
APC Conjugated
100 µl/$904
AHR Antibody - AHR antibody ARP32243_T100-NP_001612-AHR (aryl hydrocarbon receptor) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AHR Antibody (aa78-127) LS-C31439
AHR Rabbit anti-Human Polyclonal (aa78-127) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
AHR Antibody - AHR antibody ARP32243_T100-NP_001612-AHR (aryl hydrocarbon receptor) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AHR Antibody (aa78-127, HRP) LS-C427533
AHR Rabbit anti-Human Polyclonal (aa78-127) (HRP) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Chimpanzee, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
AHR Antibody - IHC analysis of AHR using anti-AHR antibody. AHR was detected in paraffin-embedded section of human placenta tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml rabbit anti-AHR Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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AHR Antibody LS-C756379
AHR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, ICC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
AHR Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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AHR Antibody (phospho-Ser36) LS-C801080
AHR Rabbit anti-Human Polyclonal (pSer36) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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