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AICDA / AID

activation-induced cytidine deaminase

Activation-induced cytidine deaminase (AICDA) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. AICDA is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms. Although AICDA is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.

Gene Name: activation-induced cytidine deaminase
Synonyms: AICDA, AID, ARP2, CDA2, Cytidine aminohydrolase, HIGM2
Target Sequences: NM_020661 NP_065712.1 Q9GZX7

Publications (3)

1
Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development. McCann KJ, Ashton-Key M, Smith K, Stevenson FK, Ottensmeier CH. Blood. 2009 113:4677-80. (IHC; Human) [PubMed:19096008] Related Antibodies: LS-B16.
2
Activation-induced cytidine deaminase expression in diffuse large B-cell lymphoma with a paracortical growth pattern: a lymphoma of possible interfollicular large B-cell origin. Aguilera NS, Auerbach A, Barekman CL, Lichy J, Abbondanzo SL. Archives of pathology & laboratory medicine. 2010 134:449-56. (IHC-P; Human) [PubMed:20196672] Related Antibodies: LS-C34861.
3
The BRCT domain of PARP-1 is required for immunoglobulin gene conversion. Paddock MN, Buelow BD, Takeda S, Scharenberg AM. PLoS biology. 2010 8:e1000428. (WB; Chicken) [Full Text Article] [PubMed:20652015] [PMC:PMC2907289] Related Antibodies: LS-C34861.

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Proteins (4)
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AICDA / AID (4)
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AICDA / AID Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
AICDA / AID Protein - 12.5% SDS-PAGE of human AICDA stained with Coomassie Blue
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Wheat Germ Extract
GST
47.52 kDa
2 µg/$439
AICDA / AID Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
23.8 kDa
20 µg/$150
AICDA / AID Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
23.8 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).