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AIFM1 / AIF / PDCD8

Apoptosis-inducing Factor, Mitochondrion-associated, 1

Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed.

Gene Name: Apoptosis-inducing Factor, Mitochondrion-associated, 1
Family/Subfamily: Apoptosis , not assigned-Apoptosis
Synonyms: AIFM1, AIF, COXPD6, PDCD8, Programmed cell death 8
Target Sequences: NM_004208 NP_004199.1 O95831

Publications (2)

1
Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury. Cao G, Xing J, Xiao X, Liou AK, Gao Y, Yin XM, Clark RS, Graham SH, Chen J. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:9278-93. (WB) [PubMed:17728442]
2
AIF inhibits tumor metastasis by protecting PTEN from oxidation. Shen SM, Guo M, Xiong Z, Yu Y, Zhao XY, Zhang FF, Chen GQ. EMBO reports. 2015 16:1563-80. (WB; Human) [Full Text Article] [PubMed:26415504] [PMC:PMC4641507] Related Antibodies: LS-C147989.

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AIFM1 / AIF / PDCD8 (22)
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AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
AIFM1 / AIF / PDCD8 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
AIFM1 / AIF / PDCD8 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$585
AIFM1 / AIF / PDCD8 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
2.74 - 2000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$851
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
6.25 - 400 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
AIFM1 / AIF / PDCD8 ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$610
AIFM1 / AIF / PDCD8 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
23.5 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$968
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).