AIRE

autoimmune regulator

The AIRE gene function is not well defined, however the protein does contain zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. The resulting protein products of these splice variants are differ significantly. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

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Proteins (5)

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Over-Expression Lysate (4)

Recombinant (1)

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AIRE (5)

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Myc-DDK (Flag) (5)

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Human (3)

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293T Cells (2)

HEK 293 Cells (3)

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Human AIRE Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67430

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.5 kDa

Price:

20 µg/$1,107

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Human AIRE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79830

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.3 kDa

Price:

20 µg/$150

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Human AIRE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79831

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.5 kDa

Price:

20 µg/$215

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AIRE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123056

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.3 kDa

Price:

100 µg/$494

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AIRE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123223

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.5 kDa

Price:

100 µg/$710

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