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AKR1B1 / Aldose Reductase

aldo-keto reductase family 1, member B1 (aldose reductase)

AKR1B1 / Aldose Reductase is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.

Gene Name: aldo-keto reductase family 1, member B1 (aldose reductase)
Synonyms: AKR1B1, Aldose reductase, ALDR1, ADR, Aldehyde reductase, Aldehyde reductase 1, ALR2, Lii5-2 CTCL tumor antigen, Low Km aldose reductase
Target Sequences: NM_001628 NP_001619.1 P15121

Publications (2)

1
Effect of Tahiti lime (Citrus latifolia) juice on the Production of the PGF2a/PGE2 and Pro-Inflammatory Cytokines involved in Menstruation. Thaiane Robeldo , Edione Fatima Canzi, Priscila Maria de Andrade , Jhonne Pedro Pedotte Santana, Felipe Roberti Teixeira, Valentine Spagnol, Beatriz Helena Lameiro Noronha Sales Maia, Maristela Carbol, Erika Gonçalves Caneira, Maria Fátima das Graças Fernandes Da Silva, Ricardo Carneiro Borra. Scientific reports. 2020 Apr;10:7063. [Full Text Article] [PubMed:32341436] [PMC:PMC7184590]
2
Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation. Keshav Gopal, Qutuba G Karwi, Seyed Amirhossein Tabatabaei Dakhili, Cory S Wagg, Liyan Zhang, Qiuyu Sun, Christina T Saed, Sai Panidarapu, Riccardo Perfetti, Ravichandran Ramasamy, John R Ussher, Gary D Lopaschuk. Cardiovascular Diabetology. 2023 March;22:73. [Full Text Article] [PubMed:36978133] [PMC:PMC10045278] Related Antibodies: LS-C331634.

☰ Filters
Antibodies (52)
ELISA Kits (8)
Proteins (8)
Custom (4)
Over-Expression Lysate (2)
Primary (52)
Recombinant (6)
Sandwich (4)
AKR1B1 / Aldose Reductase (68)
Human (54)
Mouse (21)
Rat (19)
Chimpanzee (6)
Dog (7)
Gibbon (6)
Guinea pig (3)
Horse (3)
Monkey (4)
Orangutan (6)
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Zebrafish (3)
IHC (22)
IHC-P (12)
WB (47)
Flo (1)
ELISA (16)
ICC (2)
IF (7)
IP (2)
Peptide-ELISA (3)
rabbit (46)
mouse (6)
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IgG (32)
IgG1 (1)
IgG1,k (1)
monoclonal mc (5)
polyclonal pc (47)
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96-Well Strip Plate (8)
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Unconjugated (38)
N-Terminus (4)
aa201-250 (4)
210-290 aa, C-terminal (1)
C-Terminus (1)
Lys275 (1)
aa1-50 (1)
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aa102-135 (1)
aa226-275 (1)
aa241-290 (1)
aa290-316 (1)
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Human (7)
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Biologically active (1)
AKR1B1 / Aldose Reductase Antibody - Immunohistochemical analysis of Aldose Reductase staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
AKR1B1 / Aldose Reductase Antibody - Anti-AKR1B1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
AKR1B1 / Aldose Reductase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
AKR1B1 / Aldose Reductase Antibody - Western blot analysis of extracts of various cell lines, using AKR1B1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
AKR1B1 / Aldose Reductase Antibody - Anti-AKR1B1 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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AKR1B1 / Aldose Reductase Mouse anti-Human Monoclonal (2D12) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
AKR1B1 / Aldose Reductase Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using AKR1B1 Polyclonal Antibody at dilution of 1:40.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
AKR1B1 / Aldose Reductase Antibody - Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AKR1B1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal (aa290-316) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
AKR1B1 / Aldose Reductase Antibody - Anti-AKR1B1 / Aldose Reductase antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal (aa241-290) Antibody
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
AKR1B1 / Aldose Reductase Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using AKR1B1 Antibody at dilution of 1:100
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
AKR1B1 / Aldose Reductase Antibody - Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AKR1B1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal (aa102-135) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
AKR1B1 / Aldose Reductase Antibody - Western blot of Aldose Reductase antibody
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal (210-290 aa, C-terminal) Antibody
Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
AKR1B1 / Aldose Reductase Antibody - IHC of Aldose Reductase (K275) pAb in paraffin-embedded human lung carcinoma tissue.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal (Lys275) Antibody
Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
AKR1B1 / Aldose Reductase Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$317; 500 µg/$526; 20 µg/$245
AKR1B1 / Aldose Reductase Antibody - AKR1B1 was detected in paraffin-embedded sections of rat intestine tissues using rabbit anti- AKR1B1 Antigen Affinity purified polyclonal antibody
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
AKR1B1 / Aldose Reductase Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using AKR1B1 Polyclonal Antibody at dilution of 1:30.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
AKR1B1 / Aldose Reductase Antibody - Immunohistochemistry of paraffin-embedded Human ovarian cancer using AKR1B1 Polyclonal Antibody at dilution of 1:40.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
AKR1B1 / Aldose Reductase Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using AKR1B1 Polyclonal Antibody at dilution of 1:40.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
AKR1B1 / Aldose Reductase Antibody - Immunohistochemistry of paraffin-embedded rat lung using AKR1B1 Antibody at dilution of 1:100 (40x lens).
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
AKR1B1 / Aldose Reductase Antibody - Staining HuvEc cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$412
Select
AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
AKR1B1 / Aldose Reductase Antibody - Western blot of extracts of human liver cell lines, using AKR1B1 antibody.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
AKR1B1 / Aldose Reductase Antibody - IHC testing of FFPE human placenta with AKR1B1 antibody at 1ug/ml. HIER: steam sections in pH6 citrate buffer for 20 min.
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AKR1B1 / Aldose Reductase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µg/$575
AKR1B1 / Aldose Reductase Antibody - Western blot detection of AKR1B1 in C6, 3T3, Jurkat and Hela cell lysates using AKR1B1 mouse mAb (1:1000 diluted). Predicted band size: 36KDa. Observed band size: 36KDa.
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AKR1B1 / Aldose Reductase Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
Viewing 1-25 of 68 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).