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AKR1B1 / Aldose Reductase

aldo-keto reductase family 1, member B1 (aldose reductase)

AKR1B1 / Aldose Reductase is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.

Gene Name: aldo-keto reductase family 1, member B1 (aldose reductase)
Synonyms: AKR1B1, Aldose reductase, ALDR1, ADR, Aldehyde reductase, Aldehyde reductase 1, ALR2, Lii5-2 CTCL tumor antigen, Low Km aldose reductase
Target Sequences: NM_001628 NP_001619.1 P15121

Publications (2)

1
Effect of Tahiti lime (Citrus latifolia) juice on the Production of the PGF2a/PGE2 and Pro-Inflammatory Cytokines involved in Menstruation. Thaiane Robeldo , Edione Fatima Canzi, Priscila Maria de Andrade , Jhonne Pedro Pedotte Santana, Felipe Roberti Teixeira, Valentine Spagnol, Beatriz Helena Lameiro Noronha Sales Maia, Maristela Carbol, Erika Gonçalves Caneira, Maria Fátima das Graças Fernandes Da Silva, Ricardo Carneiro Borra. Scientific reports. 2020 Apr;10:7063. [Full Text Article] [PubMed:32341436] [PMC:PMC7184590]
2
Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation. Keshav Gopal, Qutuba G Karwi, Seyed Amirhossein Tabatabaei Dakhili, Cory S Wagg, Liyan Zhang, Qiuyu Sun, Christina T Saed, Sai Panidarapu, Riccardo Perfetti, Ravichandran Ramasamy, John R Ussher, Gary D Lopaschuk. Cardiovascular Diabetology. 2023 March;22:73. [Full Text Article] [PubMed:36978133] [PMC:PMC10045278] Related Antibodies: LS-C331634.

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
AKR1B1 / Aldose Reductase (8)
No (8)
GST (1)
GST, N-terminus (1)
His (1)
His,N-terminus (1)
Myc-DDK (Flag) (3)
Human (7)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (1)
Biologically active (1)
AKR1B1 / Aldose Reductase Protein
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E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$317; 500 µg/$526; 20 µg/$245
AKR1B1 / Aldose Reductase Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
AKR1B1 / Aldose Reductase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35.7 kDa
100 µg/$494
AKR1B1 / Aldose Reductase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
AKR1B1 / Aldose Reductase Protein - 12.5% SDS-PAGE of human AKR1B1 stained with Coomassie Blue
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Wheat Germ Extract
GST
60.39 kDa
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
35.7 kDa
20 µg/$150
AKR1B1 / Aldose Reductase Protein - Purified recombinant protein AKR1B1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35.7 kDa
20 µg/$1,107
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E. coli
His,N-terminus
37.9 kDa
100 µg/$600
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).