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AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
| Gene Name: | aldo-keto reductase family 1, member B10 (aldose reductase) |
| Synonyms: | AKR1B10, AKR1B11, Aldose reductase-like peptide, ALDRLn, AKR1B12, Aldose reductase-like, Aldose reductase-like 1, ARP, HARP, HSI, Small intestine reductase, ARL-1, SI reductase |
| Target Sequences: | NM_020299 NP_064695.3 O60218 |
Publications (6)
1
Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. Yan R, Zu X, Ma J, Liu Z, Adeyanju M, Cao D. International journal of cancer. Journal international du cancer. 2007 121:2301-6.
[PubMed:17597105]
2
Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. Ma J, Yan R, Zu X, Cheng JM, Rao K, Liao DF, Cao D. The Journal of biological chemistry. 2008 283:3418-23.
[PubMed:18056116]
3
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10. Quinn AM, Harvey RG, Penning TM. Chemical research in toxicology. 2008 21:2207-15.
[PubMed:18788756]
[PMC:PMC2645959]
☰ Filters
Products
Proteins
(7)
Type
Over-Expression Lysate
(2)
Recombinant
(5)
Target
AKR1B10
(7)
Publications
No
(7)
Tag
GST
(1)
GST, N-terminus
(2)
Myc-DDK (Flag)
(3)
Species
Human
(6)
Source
293T Cells
(1)
E. coli
(2)
HEK 293 Cells
(2)
Wheat Germ Extract
(2)
Purification
Purified
(2)
Biologically Active
Biologically active
(1)
E. coli
None
Biologically active
100 µg/$361; 500 µg/$739; 20 µg/$261
Wheat Germ Extract
GST
60.5 kDa
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
35.8 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
35.8 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
35.8 kDa
100 µg/$494
E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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