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AKR1C4 / Chlordecone Reductase

aldo-keto reductase family 1, member C4

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Gene Name: aldo-keto reductase family 1, member C4
Synonyms: AKR1C4, 3-alpha-HSD, 3-alpha-HSD1, Chlordecone reductase, CDR, CHDR, DD-4, Dihydrodiol dehydrogenase 4, C11, DD4, HAKRA
Target Sequences: NM_001818 NP_001809.3 P17516

☰ Filters
Products
Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
AKR1C4 / Chlordecone Reductase (8)
No (8)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (7)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (2)
Biologically active (1)
AKR1C4 / Chlordecone Reductase Protein
Select
E. coli
His
Biologically active
100 µg/$361; 500 µg/$739; 20 µg/$261
AKR1C4 / Chlordecone Reductase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.9 kDa
20 µg/$150
AKR1C4 / Chlordecone Reductase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
36.9 kDa
100 µg/$494
AKR1C4 / Chlordecone Reductase Protein - 12.5% SDS-PAGE of human AKR1C4 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
61.27 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.3kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
AKR1C4 / Chlordecone Reductase Protein - Purified recombinant protein AKR1C4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
36.9 kDa
20 µg/$1,107
AKR1C4 / Chlordecone Reductase Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.3 kDa
10 µg/$344; 50 µg/$584
Viewing 1-8 of 8 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).