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Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Gene Name: | aldo-keto reductase family 1, member D1 |
Synonyms: | AKR1D1, 3o5bred, SRD5B1, CBAS2 |
Target Sequences: | NM_005989 NP_005980.1 P51857 |
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