AKT3

v-akt murine thymoma viral oncogene homolog 3

AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

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Products

Proteins (12)

Type

Over-Expression Lysate (4)

Recombinant (8)

Target

AKT3 (12)

Publications

No (12)

Tag

GST (1)

GST, N-terminus (2)

His/GST,N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (6)

Species

Human (8)

Mouse (2)

Source

293T Cells (2)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (4)

Insect Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

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Human AKT3 Protein (Recombinant His-T7) (aa46-338) - LS-G12088

Source:

E. coli

Tag:

His-T7

Molecular Weight:

37.9 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human AKT3 Protein (Recombinant GST) (Full Length) - LS-G31889

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.32 kDa

Price:

10 µg/$479; 25 µg/$670

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Human AKT3 Protein (Recombinant GST, N-terminus) (aa100-189) - LS-G61318

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse AKT3 Protein (Recombinant) (Ala106-Glu479) - LS-G98047

Source:

Baculovirus

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.4 kDa

Price:

50 µg/$707

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Human AKT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86319

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.6 kDa

Price:

20 µg/$215

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Human AKT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86320

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.9 kDa

Price:

20 µg/$215

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AKT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104425

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.9 kDa

Price:

100 µg/$710

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Human AKT3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70126

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.6 kDa

Price:

20 µg/$1,107

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Human AKT3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70127

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.9 kDa

Price:

20 µg/$1,107

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AKT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100558

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.6 kDa

Price:

100 µg/$710

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Human AKT3 Protein (Recombinant GST, N-terminus) (Met1-Glu479) - LS-G139927

Source:

Insect Cells

Tag:

GST, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

81 kDa

Price:

50 µg/$661

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Mouse AKT3 Protein (Recombinant His/GST,N-terminus) (Ala106-Glu479) - LS-G139935

Source:

Insect Cells

Tag:

His/GST,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71 kDa

Price:

50 µg/$661

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